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KMID : 0604520090350040257
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Journal of the Society of Cosmetic Scientists of Korea
2009 Volume.35 No. 4 p.257 ~ p.263
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The Study on the Whitening Effects of Traditional Chinese Medicines
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Chou Guixin
Zhu Enyuan
Lee Su-Yeon
Kim Young-Heui
Park Sun-Ki
Oh Sun-Tack
Kim Ki-Ho
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Abstract
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In order to search for new whitening cosmetic ingredients from Chinese herbal extracts including Chinese herbs and complex prescriptions from TCM (Traditional Chinese Medicine), we screened about 47 TCM extracts collected from China. We tested their inhibitory effects on melanogenesis by using in vitro tyrosinase inhibition assay and B16 melanoma cells. We selected Siphonostegia chinensis and Salvianic miltiorrhiza Bunge. We isolated Danshensu (,3,4-trihydroxybenzenepropanoic acid sodium salt) from Salvianic miltiorrhiza Bunge extract and tested its inhibitory effect on melanin formation in B16-F10 melanoma cells. Danshensu suppressed melanin synthesis up to about 50% at a concentration of . Siphonostegia chinensis suppressed melanin synthesis up to about 60% at a concentration of . The results showed that these extracts could be used as new natural active ingredients for whitening cosmetics.
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KEYWORD
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melanin, TCM, B16-F10 melanoma, whitening, Siphonostegia chinensis, sodium danshensu
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